Leukemic transformation among 1306 patients with primary myelofibrosis: risk factors and development of a predictive model
نویسندگان
چکیده
منابع مشابه
JAK2 V617F mutational status predicts progression to large splenomegaly and leukemic transformation in primary myelofibrosis.
Few investigators have evaluated the usefulness of the JAK2 V617F mutation for explaining the phenotypic variations and for predicting the risk of major clinical events in primary myelofibrosis (PMF). In a transversal survey we assayed by allele-specific polymerase chain reaction (PCR) the JAK2 V617F mutational status in 304 patients with PMF. Multiple DNA samples were collected prospectively f...
متن کاملThrombosis in primary myelofibrosis: incidence and risk factors.
We assessed frequency and predictive factors for major cardiovascular (CV) events in 707 patients with primary myelofibrosis (PMF) followed in 4 European institutions. A total of 236 deaths (33%) were recorded for an overall mortality of 7.7% patient-years (pt-yr). Fatal and nonfatal thromboses were registered in 51 (7.2%) patients, with a rate of 1.75% pt-yr. If deaths from non-CV causes were ...
متن کاملAn Epidemiologic Model for Risk Factors of Migraine and Tension type Headaches among Primary Schools Teachers of Shiraz, 2003.
This study was conducted to estimate the prevalence of migraine and tension-type headaches among Shiraz primary schools teachers and to provide an epidemiologic model for them. A random sample of 538 teachers, constituting a 10% sample of the primary schools teachers’ population, was evaluated on the basis of the diagnostic criteria of the International Headache Society (IHS) as well as clinica...
متن کاملPrimary myelofibrosis and extramedullary blastic transformation with hemophagocytosis
which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. A 72-year-old woman presented with bleeding, swollen gums, and painful cervical lymphadenopathy. A CT scan revealed diffuse lymphadenopathy and hepatosplenomegaly. Initial laboratory tests showed the following: WBC level, 11.1 μg/mL; and a differential count...
متن کاملLeukemic transformation in myelofibrosis with myeloid metaplasia: a single-institution experience with 91 cases.
Among 2333 consecutive patients with myelofibrosis with myeloid metaplasia (MMM) seen at our institution, 91 fulfilled the World Health Organization (WHO) criteria for leukemic transformation (LT). All episodes of LT were myeloid in origin (acute myeloid leukemia [AML]) with all French-American-British (FAB) subtypes represented except M3; the most frequent subtypes were M7 (25.4%), M0 (22.4%),...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood Cancer Journal
سال: 2019
ISSN: 2044-5385
DOI: 10.1038/s41408-019-0175-y